Ingredients in Vaccines

Often, We come across people opposing vaccines based on wrong notion. For example, in the Facebook Post by Dr.Prakash, an excellent and eminent surgeon, the following comment was posted

Anti vaxxers are Fools, Anti Socials, Serial Killers and Unfit to live

Here is the response

//The list is bit shocking and I need your explanation for those items in that list..//

What is there to be shock ? The explanation is right there ? Some excipients are added to a vaccine for a specific purpose. These include:

  • Preservatives, to prevent contamination. For example, thimerosal.
  • Adjuvants, to help stimulate a stronger immune response. For example, aluminum salts.
  • Stabilizers, to keep the vaccine potent during transportation and storage. For example, sugars or gelatin.

Others are residual trace amounts of materials that were used during the manufacturing process and removed.

  • These can include:Cell culture materials, used to grow the vaccine antigens. For example, egg protein, various culture media.
  • Inactivating ingredients, used to kill viruses or inactivate toxins. For example, formaldehyde.
  • Antibiotics, used to prevent contamination by bacteria. For example, neomycin.

What is there to be shocking here ? And what is the explanation ?



And here is the full details from that Vaccine Excipient Summary table http://www.insulingate.com/wp-content/uploads/2020/07/excipient-table-2.pdf

//These people are not against vaccine but want a safe medicine for their loved ones…//

Even Oxygen has toxicity. If some one says that he wants a safe oxygen
What will be your respone ?  You will consider him a fool. Isn’t it ? Same way
We consider those who oppose vaccines citing meagre side effects as FOOLS and STUPIDS

And

What if some one comes and closes your mouth asking you not to breathe oxygen since it is toxic ? you will call him Anti Social, Killer and Unfit to live

That is why we brand Anti Vaxxers in these names. Any doubts sir ?



//you are branding people those who question the efficacy of vaccine as Anti vaxxers.. ..//

Not just anti vaxxers . . We also brand them as Fools, Anti Socials, Serial Killers and those who are Unfit to live

Anti Rabies Vaccine for Dog Bite. Availability in Primary Health Centre and Medical College

Some Times Truth is Stranger than Fiction
So
Let me share a real fact.

-oOo-

I joined Tamil Nadu Medical Services in 2004 and worked for three years in Primary Health Centres. In Primary Health Centres, Run by Department of Health, Government of Tamil Nadu, we used to give ARV (Anti Rabies Vaccine) any time the patient walks in.

And then
I came to Madras Medical College, a tertiary care institution and was shocked to find that Vaccines are given only from 8 AM to 11 AM and that too only on Working Days. . . I could not comprehend the rationale. I am sure that Dogs in areas round the medical college hospital do not follow Calendar and Watch when biting on unsuspecting individuals

-oOo-



So, you have two hospitals run by the Same Government, Same Ministry, Same Minister, Same Health Secretary

  1. A 24x7x365 Tertiary Care Hospital, with nearly 1000 doctors working and around 5000 beds, where Vaccines for dog bite are given only 3 hours for 6 days a week
  2. A Primary Health Centre, with just two doctors, where vaccines for dog bite are given any time the patient walks in

Logic says that you will expect better service in a Tertiary Care Hospital
But
In Reality, Primary Health Centres Provide Better Service

So, the administrative fact that is really fiction is that Tertiary Health Care gives better service 🙂

I did try to analyse why this happened and found the reason too

It was because

Anti Rabies Vaccine Multi Dose Vial

Earlier, Vaccines came in Multi Dose Vial. That is in a single bottle (or ampoule) there were many doses. So, they took the bottle out of the fridge and wanted to finish it off quickly. So they made people come within a narrow time window
But
Now, vaccines come in single dose vial. Only one dose in a bottle (or ampoule). So they can open the vial, give the injection and need not worry about keep it safe again

Anti Rabies Vaccines started in Medical Colleges a long time ago, So they followed the narrow time window. They did not think to change it when multi dose vials got replaced by single dose vials. They did not apply their mind. They did not take the new scientific advancement to their advantage. It is like a person who started using bicycle, continuing in bicycle even after two wheelers were invented

Anti Rabies Vaccine Single Dose Vial

But
Primary Health Centres, where they recently started Anti Rabies Vaccines and at that time, they had single dose vials. So they did not have any time window

This also underlies lessons in Management :

  1. All Protocols need to be reviewed at regular intervals and see whether a new and better protocol be introduced taking into account a recent invention or scientific advancement
  2. Smaller institutions may have better protocols. So learning should be two way and the bigger institutions need not always push their ideas